TissueGen is a developer of next generation drug delivery technologies. TissueGen solves for unmet needs through the development of transformative drug delivery technologies that reduce treatment burden and improve clinical outcomes. We create life changing treatment modalities for patients and their caregivers, treating both acute and chronic conditions.

86 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Alternative to Animal Testing for Drug Development Cherry Biotech is a biomedical technology (Organ on Chip) company that develops instruments for drug discovery and personalised medicine. Its mission is to replace animal testing by reconstructing human tissue (Organoids) in vitro for drug testing. Cherry Biotech's CUBIX platform enables pharmaceutical, biotech companies and healthcare providers to recreate immunocompetent human vascularized organ models and tumor microenvironments for better evaluation of their drug candidates. By enabling the reconstruction of human 3D models that mimic human physiology and pathophysiology over several weeks, Cherry Biotech's proprietary CUBIX technology is the only solution that can convert …

141 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Transform how you model human biology. Ricoh Biosciences is a global leader in biotechnology, headquartered in the Science + Technology Park at the Johns Hopkins Medical Campus in Baltimore, MD. Our mission is to advance science and medicine with fast, functional, and scalable induced pluripotent stem cell (iPSC) differentiation products and services. Our state-of-the-art, transcription-factor-based technology allows you to overcome the high cost and inefficiencies associated with lengthy cell differentiation periods. We empower research institutions, pharmaceutical organizations, and biomedical enterprises worldwide, even those with no previous iPSC experience, by increasing access to relevant cells for modeling human biology and accelerating …

91 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Life, reimagined. Constructive Bio designs and manufactures proteins with chemistries that don't exist in nature. By rewriting the genetic code, we give cells access to entirely new chemical building blocks, then scale what we find into medicines and materials that couldn't exist before. Our BioForge platform turns advanced molecular designs into manufacturable reality: complex peptides, site-specific conjugates, covalent biologics, and oral therapeutics that conventional synthesis cannot reliably produce. Constructive and its partners shift the question from "can we make this?" to "what should we make next?". Synthetic Biology, Genome engineering, Biopolymers, Protein engineering, Therapeutics, Biomanufacturing, and Genetic code expansion

77 similar entities Type: Startup Activities: it services deeptech Technologies: Synthetic Biology

‘Off-the-Shelf’ Curative Cell Therapies About Us: Cell BioEngines is a US-based clinical-stage biotechnology company developing off-the-shelf allogeneic cell therapies by chemically reprogramming stem cell fate and function to treat serious and currently incurable diseases. Leveraging cord blood stem cells from highly compatible 'super-donors' and powered by its proprietary STEM-Space cellular reprogramming platform, the company delivers scalable cell products with reduced risk of immune rejection. Cell BioEngines’ competitive edge comes from a unique combination of a transgene-free scalable manufacturing platform enabled by advanced chemical reprogramming, rigorous HLA-guided design, and a population-informed biobank that supports broad patient coverage. Cell BioEngines lead clinical …

311 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

The Precision Vaccines Company Belyntic creates novel vaccines for viral diseases with unmet medical need. We have developed and validated a new platform technology, that generates self-adjuvant synthetic long peptides for a safe and durable induction of cellular immunity. Drug development, Cellular immunity, and Platform technology

260 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Seed Therapeutics is pioneering the science of improving human health by creating “molecular glues”: novel therapeutics that degrade disease-causing proteins that have heretofore remained “undruggable.” Through ongoing collaborations with world-leading academic experts in the field, and in partnership with seasoned drug development and commercialization experts, Seed Therapeutics is establishing a growing pipeline of exciting drug candidates on a path to clinical and commercial success. Our mission is to positively impact human health by creating novel protein degradation therapeutics for the treatment of severe diseases for which health care professionals currently have limited options to offer to patients. Biotechnology, Biotherapeutics, Cell …

201 similar entities Type: SMB Activities: biotech deeptech Technologies: Synthetic Biology

Cure with genes Healthy cells for healthy people Somagenetix is a new company that aims at becoming a leading gene therapy company with first-in-class treatment for phagocyte-related disorders. We are spin-off from the University of Zurich and we are leveraging world-class scientific and clinical expertise to solve unmet medical needs through gene therapy. Carried by a highly experienced scientific team with over 17 years experience in gene therapy research, clinical development and applications, our mission is to cure all patients with Phagocyte Disorders. A cutting-edge technology with a complete & unique platform solving all challenges of ex-vivo gene therapies: specificity, …

77 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Galvani Bioelectronics is a joint venture between GSK and Verily Life Sciences. We are devoted to the development of life changing neuromodulation therapies for patients with chronic disease. Medical Devices

103 similar entities Type: SMB Activities: deeptech healthtech Technologies: Synthetic Biology

Changing the course of CNS disease Evox Therapeutics is harnessing and engineering the natural trafficking capabilities of extracellular vesicles to develop an entirely novel class of biotherapeutics. By combining groundbreaking exosome technology from well-renowned Oxford University and the Karolinska Institutet – the home of the Nobel Prize – we aim to revolutionise the treatment of a broad range of severe disease, with profound implications for human health. Based in Oxford, UK, Evox Therapeutics was founded in 2016 by Professor Matthew Wood of Oxford University, Assistant Professor Samir EL Andaloussi and Dr Per Lundin of the Karolinska Institutet, to capitalise on …

78 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Seamless Therapeutics is overcoming the boundaries of gene editing by unlocking the full potential of recombinases. Seamless Therapeutics is changing the paradigm of gene editing through a pioneering approach to restore health in patients with severe conditions in a safe and precise manner. Our technology platform unlocks the reprogramming of recombinases, a highly versatile class of enzymes. We are applying our proprietary know-how to develop a pipeline of disease-modifying product candidates across a broad spectrum of indications to expand the therapeutic potential of gene editing.

63 similar entities Type: Startup Activities: deeptech healthtech Technologies: Synthetic Biology

Restore your body through the power of self-regeneration Founded in 2020, Healshape is a French global regenerative medicine company, with a clear mission: “Enabling people to restore their physical integrity through self-regeneration”. We are committed to transforming the way soft tissue reconstruction is approached, moving away from synthetic implants and toward biological harmony. Biotechnology, Regenerative medecine, Médecine régénérative, Reconstruction mammaire, Cancer du sein, Breast cancer, Breast regeneration, Breast reconstruction, 3D bioprinting, Tissue engineering, Biologie cellulaire, Impression 3D, Funds raising, Tissue engineered products, Lyon, France, self-regeneration, and Start-up

86 similar entities Type: Startup Activities: deeptech Technologies: 3D Printing Synthetic Biology

AveXis is now Novartis Gene Therapies Novartis Gene Therapies (formerly AveXis) is reimagining medicine to transform the lives of people living with rare genetic diseases. Utilizing cutting-edge technology, we are working to turn promising gene therapies into proven treatments, beginning with our transformative gene therapy for spinal muscular atrophy (SMA). Follow us on LinkedIn: https://www.linkedin.com/company/novartis-gene-therapies/ How to reach us: Novartis Gene Therapies 2275 Half Day Road, Suite 200 Bannockburn, IL 60015 Email: gtx.communications@novartis.com Office Phone: 847.572.8280 Toll-free Phone: 844.428.3947 Gene Therapy, Synthetic Biology, and Spinal Muscular Atrophy

221 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

A Wholly Owned Subsidiary of Eli Lilly and Company Kelonia is pioneering a new wave of genetic medicines using its next generation gene delivery platform. The company’s simple and elegant cutting-edge in vivo gene delivery technology uses a few potent lentiviral vector-like particles to precisely and efficiently deliver in vivo genetic cargo to the desired target tissue, and only that tissue, every time. With an initial focus on developing transformational therapies for solid tumors and hematologic cancers, Kelonia is building a pipeline of genetic medicines for a wide range of diseases, with the bold goal of bringing genetic medicines to …

61 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Reconcile the time of Research with the one of Medecine APTEΞUS was created to provide clinicians and their patients suffering from orphan diseases, an innovative service of clinical biology that perfectly meets the emerging challenge of individualized medicine. APTEΞUS is engaged in patient-centric discovery of individualized treatments. Our technology allows the testing of thousands of molecules directly on primary cells sampled from patient with inborn error of metabolism. We can rapidly identify molecules that specifically correct the very molecular defect of the patient and give him a new opportunity to be cured.

112 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

The CanVas platform is focused on developing novel cell therapies. The CanVas platform is spearheading the development of investigational allogeneic candidates for neurologic, rare and other serious diseases. Our world class team are dedicated to advancing a wave of investigational allogeneic products through excellence in translational research, clinical development and cell manufacturing. We are developing a pipeline of off-the-shelf cell therapies based on the pioneering Can-Vas platform. This could allow for the delivery of cell therapies to patients faster when they need it most and at greater scale. Our mission is to have a transformative impact on patients’ lives by …

245 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Modulating T-regulatory cells to balance immunity Egle Therapeutics has been founded with a vision to become a game changer in the field of immunomodulating T-regulatory cells (Tregs) through the unique concept of Tregs’ starving while specifically targeting the most immunosuppressive ones.

137 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

We Empower Cells In Vivo to Fight Diseases. EsoBiotec is a biotechnology company developing innovative therapeutics to fight cancer. Our mission is to empower the human body to tackle cancer by bringing in vivo engineering of cells to patients. We aim to develop cost-effective and off-the-shelf therapeutics and providing state-of-the-art cell therapies to maximise accessibility. Our disruptive approach holds the potential to transform the current standard of cell and gene therapies for cancer treatment. Gene therapy, Biotechnology, Oncology, Cell therapy, Cancer, in vivo engineering, virology, and Immunology

216 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Gecko Biomedical is a fast-paced medical device company, dedicated to the development of innovative tissue reconstruction solutions. We are leveraging our technology platforms to develop novel solutions to disrupt the field of surgery and positively impact the life of patients.

153 similar entities Type: Startup Activities: healthtech deeptech Technologies: Synthetic Biology

Gradiant Bioconvergence (GBCC) is Korea's first organoid-focused company. We built the country's largest patient-derived organoid biobank, spanning nearly 1,000 models across lung, gastric, colorectal, pancreatic, ovarian, and breast cancer, with accompanying NGS data. Our scientific advisory board includes Dr. Toshiro Sato, a co-inventor of the foundational organoid technology and a former lab member of Dr. Hans Clevers, and Dr. Byoung Chul Cho, a professor of medical oncology at Yonsei University College of Medicine and chief of the Lung Cancer Center at Yonsei Cancer Center.

78 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Synthetic Genetic Systems for next generation biomedicines and bioprocesses. SynGenSys creates product-specific libraries of synthetic genetic parts for next-generation biomedicines and biomanufacturing processes. Our philosophy is simple: all products and production processes are unique. Therefore core genetic assemblies used for therapy or biomanufacturing should harbour custom synthetic DNA parts and circuits designed to be fit for a specific purpose. Life Science, Biopharma, Cell Therapy, and Gene Therapy

82 similar entities Type: Startup Activities: deeptech Technologies: Synthetic Biology

The new way of transplantation Stella Surgical is a European company based in the South of France. It was created to meet the needs of transplant surgeons, procurement and transplant teams, and organ transporters. Our promise: to increase the number of grafts available, and their safety during the entire transplantation process. Thus, we design, develop and market connected and innovative medical devices so that the coordination teams (harvesting and transplant) can plan transplants in the best possible conditions. Patients will therefore be able to benefit from better conditions during their transplant.

65 similar entities Type: SMB Activities: manufacturing deeptech healthtech Technologies: Synthetic Biology

At Orio Therapeutics, our mission is to save lives by making the regenerative medicine dream accessible and a wide-spread reality. We are dedicated to developing novel regenerative drugs with increased efficacy and reduced side-effects, using cutting-edge targeted drug-delivery technologies to create novel therapeutic proteins. Notably, we strive to demonstrate that efficient drug delivery technologies are not confined to the development of complex devices and drug carriers but can be achieved based on clever molecular designs. We aim to initially validate our program pipeline through the development of a therapeutic molecule for myocardial infarction that has the potential to change the …

119 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

"Designs the immunotherapy of tomorrow" At Allogenica, we are transforming cell therapies for a healthier tomorrow. Our mission is to disrupt the treatment landscape for cancer, rare diseases, and autoimmune disorders. We're developing a breakthrough cell therapy platform with the potential to: • Replace transplants: Providing less invasive, accessible alternatives for thousands of patients who currently have limited treatment options. • Expand access for all: With predictable safety and efficacy, we aim to make cell therapies available to a a broader patient population. • Dramatically reduce costs: By streamlining production, we aim to significantly lower the cost of cell therapies, …

178 similar entities Type: Startup Activities: deeptech biotech healthtech Technologies: Synthetic Biology

Curing blindness with regenerative cell therapies. StemSight develops off-the-shelf regenerative cell therapies for corneal blindness. Our expertise is in the combination of iPS-derived cells with functional biomaterials - for FASTER tissue regeneration, SAFER cell therapies and EASIER cell delivery.

64 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Personalized Transplants VERIGRAFT generates personalized tissue-engineered transplants for use in regenerative medicine. The company’s unique technology platform turns donated allogeneic (“foreign”) tissue into an autologous-like (“personalized”) tissue and thus avoids transplant rejection and the need for life-long immunosuppression. Donated, allogenic tissue is patient-individualized by a combination of DC (Decellularization) and RC (Reconditioning/Recellularization) processes. VERIGRAFT’s development pipeline comprises products in the areas of vascular regeneration as well as peripheral nerve repair.

65 similar entities Type: SMB Activities: biotech deeptech Technologies: SaaS

Transformative vascular implants. Addressing major life-threatening diseases, backed by Nobel-winning science. Xeltis is developing artificial vessels and valves that are gradually replaced by patients’ own living healthy tissue. www.xeltis.com

95 similar entities Type: SMB Activities: healthtech deeptech Technologies: Synthetic Biology

Ultimate predictability Since 1999, genOway aims at bridging the gap between preclinical findings and clinical success with advanced, genetically engineered preclinical models and solutions. From customized mice and rats to ready-to-use cell lines, our solutions provide increased predictability and accelerate therapeutic breakthroughs. We work with 17 of the world’s Top pharma companies—as well as leading biotech firms, CROs, and academic institutions. At the heart of genOway is a team of 150+ skilled professionals, from 17 nationalities, all committed to advancing preclinical research. What We Offer • A catalogue of validated, ready-to-use mice and cell lines—developed in partnership with biopharma leaders …

148 similar entities Type: SMB Activities: biotech deeptech Technologies: Synthetic Biology

A Path to SuperCellsTM Therapies GC Therapeutics Inc. (GCTx) uses synthetic biology to program patient-derived stem cells into any cell type with best-in-class efficiency (up to 10X), speed (up to 100X) and scalability. We dictate cells fates in a single step and have validated cells for many applications. We have also developed SuperCellsTM by tailoring cells for specific diseases. The core technology of GCTx was conceived, invented and perfected in Professor George Church’s lab at Harvard Medical School. We are a group of passionate biologists and tissue engineers whose goal is to bring this breakthrough approach to patients.

159 similar entities Type: SMB Activities: biotech deeptech healthtech Technologies: Synthetic Biology

Unlocking in vivo cell therapy with the next generation of gene editing technology Brink Therapeutics is developing next-generation recombinases — ultra-precise and efficient enzymes that surpass CRISPR-Cas9. We aim to revolutionize Cell and Gene therapies, enabling large-scale production to treat cancer, genetic disorders, and other diseases.

105 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

A scalable in-vivo genetic medicine platform At Immitra Bio, we are pioneering a novel genetic medicine platform. Our innovative approach enables precise, durable, and safe gene modifications within blood stem cells, laying the foundation for scalable, curative in-vivo therapies.

122 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Reversing Neurodegeneration - Restoring Life GeneCode is developing small-molecule drugs that bind and activate GDNF (Glial cell line-Derived Neurotrophic Factor) receptors for the treatment of Parkinson’s disease (PD) and other neurodegenerative conditions.

119 similar entities Type: SMB Activities: biotech deeptech Technologies: Synthetic Biology

Pharmaceutical drug development company, focusing on late-stage development for treatment of serious rare diseases. Egetis is an innovative and integrated pharmaceutical company, focusing on projects in late-stage development for commercialization for treatments of serious diseases with significant unmet medical needs in the orphan drug segment

67 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

The platform for creating organs and tissues in the lab. The platform for creating organs and tissues in the lab. Biotechnology, Biomaterials, Bioprinting, 3D Cell Culture, Tissue Engineering, Hydrogels, Regenerative Medicine, Research, and Tissue Culture

128 similar entities Type: Startup Activities: deeptech Technologies: Synthetic Biology

Exosome-based therapeutics Exogenus Therapeutics is an innovative biotech start-up dedicated to early stage development of therapeutic tools. Using an exosome-based platform technology, Exogenus is developing biologic products for diseases with high unmet needs, such as inflammatory and autoimmune diseases. Driven by the urgency imposed by the COVID-19 pandemic, the company is currently developing solutions for the treatment of severe lung inflammation, a condition with limited treatment options and a common cause of death following SARS‐CoV‐2 infection. Contact us at team@exogenus-t.com Biotechnology, Regenerative Medicine, Stem cells, exosomes, cell biology, and therapies

293 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Better Technology. Better Delivery. Developing a new generation of disease-modifying therapies. Driven by our proprietary Enhanced Delivery Oligonucleotide (EDO) platform, we are creating a pipeline of disease-modifying therapeutics with the potential to safely and effectively target the root cause of serious genetic neuromuscular and neurological disorders. Biotechnology, Chemistry, Biology, Bioscience, Life sciences, and Therapeutics

296 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Transforming the lives of patients through gene therapy uniQure is delivering on the promise of gene therapy - single treatments with potentially curative results. We are leveraging our modular and validated technology platform to rapidly advance a pipeline of proprietary and partnered gene therapies to treat patients with severe genetic diseases. aav, Huntington's disease, gene therapy, ALS, epilepsy, and Fabry disease

257 similar entities Type: SMB Activities: biotech deeptech healthtech Technologies: Synthetic Biology

Preserving the PromiseTM - We believe the promise of cell and gene therapies starts with the integrity of a single cell. Preserving the PromiseTM The human body can heal itself. Cell and gene therapies are designed to augment the patient’s ability to fight disease but only if the living cells behind those therapies remain viable and functional throughout the production processes. At BioLife Solutions, our mission is to protect the integrity of cells and provide trusted tools, services, and expertise that can enable our customers to advance the development and delivery of cell and gene therapies. We believe the future …

80 similar entities Type: SMB Activities: biotech deeptech Technologies: Synthetic Biology

Technology to ignite the biology revolution We are a Cambridge-based company developing a radically different approach to gene synthesis. Our desktop DNA synthesis platform will provide the ability to synthesise DNA at unprecedented accuracy, scale and speed, accelerating scientists'​ ability to use synthetic biology on a scale not currently possible. Biotechnology, Synthetic Biology, DNA synthesis, Gene synthesis, and synbio

132 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Outsmarting complex diseases with more intelligent medicines Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. To accomplish this mission, we are building a synthetic biology platform that could enable us to program next-generation cell and gene therapies with what we refer to as “gene circuits”. These gene circuits, which are created from novel and proprietary combinations of DNA sequences, are intended to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. We are designing gene circuits to improve the “intelligence” of cell …

90 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Making tissue therapeutics possible to defeat serious disease Fluicell is transforming how we treat disease with one-of-a-kind tissue solutions for regenerative medicine and drug screening. With the groundbreaking Nexocyte platform, based on twenty years of disruptive and patent-protected R&D, we are creating new ways to target serious diseases using precision-engineered biological tissues. Our transplantable tissues have the potential to help patients living with uncurable tissue damage related to cardiac, pulmonary, metabolic, kidney and other diseases. Fluicell’s first ambitious goal is to develop transplantable tissues to cure type 1 diabetes, impacting the lives of millions of patients. Nexocyte-generated tissues also enable …

98 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

A revolution in gene therapy for neurodegenerative disorders. IMPORTANT NOTICE: Fraud warning for candidates. Please click the link below under "Website" or read the following before applying: https://aviadobio.com/careers/. At AviadoBio, we are relentlessly chasing cures by translating groundbreaking science and precision delivery into life-changing medicines for people living with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). With our deep understanding of the brain and our suite of proprietary gene therapy platforms and delivery technologies, we are working relentlessly to overcome the challenges of delivering the right drug to the right place. Our innovative, neuroanatomy-led approach is designed to maximize …

159 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Shaping the future of regenerative medicine At 4Tissue, we’re pioneering the future of regenerative medicine with innovative hydrogel solutions that support natural tissue restoration. We are an innovation-led research and clinical development organization. Our mission is to redefine the boundaries of tissue reconstruction, regeneration, and anti-aging, utilizing innovative biocompatible and bioresorbable polymers platform The first product, a bioresorbable injectable hydrogel, is focused on a better cell survival and the full regeneration of adipose tissue for breast reconstruction and augmentation applications.

118 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology SaaS

Follow Astellas Pharma for updates on our pipeline of genetic medicines for patients with rare diseases. The Astellas Gene Therapies page is no longer active or monitored. gene therapy and biotechnology

81 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Oral Delivery . Genetic Breakthroughs We are a preclinical-stage biotech company focused on developing revolutionary therapies to address Inflammatory Bowel Diseases. Harnessing the unique capabilities of our Genetic Medicines Oral Delivery platform we aim to overcome major limitations of current treatments and unlock the groundbreaking potential of Genetic Medicines in IBDs, driving transformative change in a field with critical medical needs.

92 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Activating RNA, mastering disease Harnessing an innate mechanism of gene activation, MiNA Therapeutics'​ platform enables the development of new medicines that restore normal function to patients’ cells. We are applying our technology and clinical know-how to transform the therapy landscape of severe liver and other diseases. Gene activation, RNA therapeutics, Liver disease, and Drug discovery

228 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Powering the next wave of genetic medicines through superior delivery ReCode Therapeutics is a clinical-stage genetic medicines company using superior delivery to power the next wave of mRNA and gene correction therapeutics. ReCode’s selective organ targeting (SORT) lipid nanoparticle (LNP) platform is a next-generation, genetic medicines technology that enables precise delivery to target organs and cells beyond the liver. RNA Therapies, Genetic Medicines, Non-Viral Lipid Nanoparticles, Genetic Respiratory Disease, Cystic Fibrosis, Primary Ciliary Dyskinesia, and Biotechnology

148 similar entities Type: Startup Activities: deeptech biotech nanotech Technologies: Synthetic Biology

Clinical-stage lentiviral gene therapy company, powered by plato®. Our vision: bring personalized gene therapy worldwide Our vision is to bring personalized gene therapy to the world. We target the root cause of genetic disease by introducing a functional copy of the affected gene into patients’ own hematopoietic stem cells (HSCs), with the goal of durably expressing the therapeutic protein throughout the body, including the central nervous system. Our first-in-class pipeline includes clinical programs for Gaucher disease and Hunter syndrome, as well as a preclinical program for Pompe disease. Our proprietary plato® gene therapy platform is scalable for planned global commercialization. …

193 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

The Uniqueness of Individualized Neoantigen Cancer Vaccine to Reshape the Future of Early-Stage Cancer Treatment Cancer immunotherapy Transgene (Euronext: TNG) is a clinical-stage biotechnology company focused on individualized therapeutic vaccines

166 similar entities Type: SMB Activities: deeptech biotech Technologies: Synthetic Biology

Developing the Next Generation Gene Editing Technology Pencil Biosciences is developing a truly innovative gene modulation technology that can have an impact across a range of applications, including new therapeutic options for patients with rare diseases. Genome Engineering, Research and Development, and Gene Editing

183 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Pioneering cellular rejuvenation using epigenetic restoration to reverse diseases of aging At Life Biosciences, we are on a mission to reverse age-related diseases. Our platform, termed epigenetic restoration, has been shown to rejuvenate cells in preclinical models with profound therapeutic effect. It has the potential to rejuvenate cells and restore function in many age-related diseases. We are the sole company with intellectual property covering the therapeutic use of our epigenetic restoration technology. We are also the only company to have received FDA approval to advance this technology into human clinical studies. While our initial clinical trial is for optic neuropathies, …

93 similar entities Type: Startup Activities: biotech deeptech silvertech Technologies: Synthetic Biology

Let’s cure from the beginning! Genome editing-based therapies become the predominant technology of the 21st century with promising statements about genetic diseases treatments. Genome editing tools recently emerged but they suffer from an absence of standardization and their applications remain limited. In this context, Quidditas developed a novel genome editing platform which permits an absolute genetic recombination. Compatible with a larger scope of applications, from bioprocess improvement to genetic disorders treatment, this revolutionary technique will have a major impact in the synthetic Bio field. So “Let’s cure from the beginning!” Genome Editing

64 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Creating Tomorrow's Immunotherapies NXI therapeutics focuses on the research and development of a new generation of selective immunosuppressive drugs for autoimmune diseases and transplantations - with objectives of high efficacy, good safety without adverse effects as seen with conventional immunosuppressants.

169 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Clinical stage biotech company focused on development of disruptive mRNA therapeutics for severe respiratory diseases Ethris is paving a new path from genes to therapeutic proteins using our proprietary messenger RNA technology. Developed in-house, our integrated platform enables the discovery, design and development of transcript therapies that restore missing functions in patients’ cells and tissues. We will advance transcript therapies to transform the treatment of disease independently and with our partners. Biotechnology, mRNA, LNPs, Vaccines, Therapeutics, Formulation, and Manufacturing

169 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Surgical tissue repair At Regenosca, we’re pioneering the future of regenerative medicine with a breakthrough platform that enables the body to heal itself—without synthetic implants or tissue grafts. Our 100% engineered, natural collagen scaffolds guide perfect tissue regeneration, offering a safer and more effective alternative to traditional treatments. With 100% success in urethra reconstruction—our initial indication in urology—demonstrated in a first-in-human trial (sustained at two-year follow-up), we’re proving the potential of our technology to transform tissue restoration across multiple medical fields. Our goal? To make tissue regeneration a reality for patients worldwide, through collaborations with clinicians, researchers, and industry partners. …

70 similar entities Type: Startup Activities: deeptech Technologies: Synthetic Biology

What If You Could Repair Broken Genes? What if you could repair broken genes? That is the question we ask ourselves every day at Editas Medicine. We’re a clinical stage genome editing company focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cas12a genome editing systems into a robust pipeline of treatments for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. We are a vibrant company full of hope, possibilities, and a belief that, working together as One …

68 similar entities Type: Startup Activities: biotech deeptech manufacturing Technologies: Synthetic Biology

Allogeneic Cell Therapy Platform that Leverages Natural Platelet Biology PlateletBio is an allogeneic cell therapy company focused on platelet biology. We are pioneers, discovering a new category in therapeutics. Our approach is one-of-a-kind, recreating nature’s legendary delivery cell. In doing so, we’re developing a cell therapy empowered to tackle previously unmet medical challenges. biotechnology, platelets, and drug discovery

459 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology

Unlocking the full potential of cell therapies for patients around the world SQZ Biotechnologies is a clinical-stage biotechnology company focused on unlocking the full potential of cell therapies to benefit patients with cancer, autoimmune and infectious diseases. The company’s proprietary Cell Squeeze® technology offers the unique ability to deliver multiple biological materials into many patient cell types to engineer what we believe can be a broad range of potential therapeutics. Our goal is to create well-tolerated cell therapies that can provide therapeutic benefit for patients and improve the patient experience over existing cell therapy approaches. With accelerated production timelines under …

186 similar entities Type: Startup Activities: deeptech biotech Technologies: Synthetic Biology

Dedicated to transforming the lives of patients with severe and other genetic diseases through innovative gene therapy. Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on ending the devastation caused by genetic and other severe diseases by discovering, developing, and commercializing new treatments that tap into the curative potential of hematopoietic stem cell (HSC) gene therapy. In this approach, a patient’s own blood stem cells are genetically modified outside of the body and then reinserted, with the goal of correcting the underlying cause of disease with a single treatment. Founded in 2015, Orchard’s roots go …

112 similar entities Type: Startup Activities: biotech deeptech Technologies: Synthetic Biology